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For better health, for convenience, for modern lifestyle demands, IQOS is evolving the way we think about tobacco

The smoke of burning tobacco has more than 7,000 chemicals with 70 known cancer-causing toxic chemicals

There are many publications investigating the interplay between nicotine and nAChRs [78, 79]

Typically, pre-filled vape pods have simple one-note flavor profiles like tobacco, mint or fruit

Healthcare providers strongly advocate for patients to quit smoking to reduce the increased risk of recurrent strokes and other cardiovascular events such as heart attack

Funding This study (YY) received financial support from the Smoking Research Foundation, Tokyo, Japan